Calcium Release Activated Calcium Channels

Specialized calcium channels that localize to the ENDOPLAMSIC RETICULUM and PLASMA MEMBRANE. They contain the pore subunit ORAI1 PROTEIN which is activated by STROMAL INTERACTION MOLECULES upon intracellular calcium depletion.

Also Known As:

CRAC Channels; Calcium Release-Activated Calcium Channels; Calcium Release-Activated Channels; Calcium Release Activated Channels; Channel, CRAC; CRAC Channel; Calcium Release Activated Calcium Channel

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Calcium Channels: 3471
        Calcium Release Activated Calcium Channels: 120
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Ion Channels: 6731
        Calcium Channels: 3471
        Calcium Release Activated Calcium Channels: 120
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Calcium Channels: 3471
        Calcium Release Activated Calcium Channels: 120

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Disease

Drug/Important Bio-Agent (IBA)